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CYP11A2

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Protein-coding gene in the species Danio rerio

cytochrome P450, family 11, subfamily a, polypeptide 2
Identifiers
OrganismDanio rerio
SymbolCYP11A2
Entrez563363
HomoloGene37347
RefSeq (mRNA)XM_686725.7
RefSeq (Prot)XP_691817.1
UniProtF1R1K0
Other data
EC number1.14.15.6
Chromosome25: 22.3 - 22.31 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The Cyp11a2 is a fish gene encoding a CYP450 monooxygenase, which was originally identified in Zebrafish (Danio rerio), is the isozyme and paralogous of fish CYP11A1, catalyzes conversion of cholesterol to pregnenolone.

References

  1. Uno T, Ishizuka M, Itakura T (July 2012). "Cytochrome P450 (CYP) in fish". Environmental Toxicology and Pharmacology. 34 (1): 1–13. Bibcode:2012EnvTP..34....1U. doi:10.1016/j.etap.2012.02.004. PMID 22418068.
  2. Parajes S, Griffin A, Taylor AE, Rose IT, Miguel-Escalada I, Hadzhiev Y, et al. (August 2013). "Redefining the initiation and maintenance of zebrafish interrenal steroidogenesis by characterizing the key enzyme cyp11a2". Endocrinology. 154 (8): 2702–11. doi:10.1210/en.2013-1145. PMID 23671259.
  3. Li N, Oakes JA, Storbeck KH, Cunliffe VT, Krone NP (February 2020). "The P450 side-chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish". The Journal of Endocrinology. 244 (2): 309–321. doi:10.1530/JOE-19-0384. PMID 31693487.
Cytochromes, oxygenases: cytochrome P450 (Most belong to EC 1.14)
CYP1
CYP2
CYP3 (CYP3A)
CYP4
CYP5-20
CYP21-49
CYP51-69
CYP71-99
CYP101-281
CYP301-499
CYP501-699
CYP701-999
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