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Cloranolol

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Cloranolol
Names

IUPAC name (RS)-1-(tert-butylamino)-3-(2,5-dichlorophenoxy)propan-2-ol
Identifiers
CAS Number	39563-28-5
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL156791
ChemSpider	59229
KEGG	D07183
PubChem CID	65814
UNII	Q3U058H86V
CompTox Dashboard (EPA)	DTXSID30865962
InChI InChI=1/C13H19Cl2NO2/c1-13(2,3)16-7-10(17)8-18-12-6-9(14)4-5-11(12)15/h4-6,10,16-17H,7-8H2,1-3H3Key: XYCMOTOFHFTUIU-UHFFFAOYAX
SMILES Clc1ccc(Cl)cc1OCC(O)CNC(C)(C)C
Properties
Chemical formula	C₁₃H₁₉Cl₂NO₂
Molar mass	292.20 g·mol
Pharmacology
ATC code	C07AA27 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references

Chemical compound

Cloranolol (Tobanum) is a beta blocker.

Synthesis

β-Adrenergic blocker. Prepn:

References

Kulcsár-Gergely J. (July 1989). "Action of beta-adrenoceptor blockers on liver function of rats". Arzneimittelforschung. 39 (7): 782–5. PMID 2571334.
G. Richter, DE 2213044, "Racemisches und optisch aktives 1-(2,5-Dichlorphenoxy)-3-tert.butylamino-2-propanol und ihre Salze, sowie ihre Verwendung und Verfahren zu deren Herstellung derselben ", published 1972-09-28, assigned to Richter Gedeon Vegyeszeti Gyar R.T. .

v t e Beta blockers (C07)
β, non-selective	Alprenolol Bopindolol Bupranolol Carteolol Cloranolol Mepindolol Nadolol Oxprenolol Penbutolol Pindolol/Iodopindolol Propranolol Sotalol Tertatolol Timolol
β₁-selective	Acebutolol Atenolol Betaxolol Bevantolol Bisoprolol Celiprolol Epanolol Esmolol Landiolol Metoprolol Nebivolol Practolol Talinolol
β₂-selective	Butaxamine
α₁- + β-selective	Arotinolol Carvedilol Labetalol
WHO-EM Withdrawn from market Clinical trials: Phase III Never to phase III

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