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Pynazolam

Identifiers
IUPAC name 1-methyl-8-nitro-6-(pyridin-2-yl)-4H-triazolobenzodiazepine
CAS Number	2034366-97-5
PubChem CID	20368157
ChemSpider	15417687
Chemical and physical data
Formula	C16H12N6O2
Molar mass	320.312 g·mol
3D model (JSmol)	Interactive image
SMILES CC1=NN=C2N1C3=C(C=C(C=C3)(=O))C(=NC2)C4=CC=CC=N4
InChI InChI=1S/C16H12N6O2/c1-10-19-20-15-9-18-16(13-4-2-3-7-17-13)12-8-11(22(23)24)5-6-14(12)21(10)15/h2-8H,9H2,1H3 Key:TULLJLNDPPOHKC-UHFFFAOYSA-N

Pynazolam is a triazolobenzodiazepine derivative first invented in the 1970s, which has in more recent years been sold online as a designer drug. Anecdotal reports and in silico studies suggest it has relatively potent hypnotic and sedative effects. Pynazolam is a powerful serotonin releaser similar to nimetazepam which increases hypnotic activity and euphoria. Anecdotal evidence has also suggested that it's subjective effects are similar to methaqualone although unlike methaqualone, it cannot be smoked or vaporised due to its high melting & boiling point.

Limited pharmacological data is available although there is an increasing availability of the compound for research purposes.

See also

• Clonazolam
• Flunitrazolam
• Nitrazolam
• Pyeazolam
• Pyrazolam
• List of benzodiazepines

References

1. US 3970664, Sternbach LH, Walser A, "Preparation of triazolo benzodiazepines.", issued 20 July 1976, assigned to Hoffmann-LaRoche, Inc. 
2. Pranzatelli, Michael R. (1989). "Benzodiazepine-induced shaking behavior in the rat: Structure-activity and relation to serotonin and benzodiazepine receptors". Experimental Neurology. 104 (3): 241–250. doi:10.1016/0014-4886(89)90036-8.
3. https://bluelight.org/xf/threads/flubromazolam-retrospective-6-years-with-the-knockout-night-nurse.892802/page-7
4. Catalani V, Floresta G, Botha M, Corkery JM, Guirguis A, Vento A, et al. (January 2023). "In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines". Chemical Biology & Drug Design. 101 (1): 40–51. doi:10.1111/cbdd.14119. hdl:2299/25749. PMID 35838189.
5. https://pubchem.ncbi.nlm.nih.gov/compound/20368157

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